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Mat. Biolog. Bioinform., 2012, Volume 7, Issue 2, Pages 703–736 (Mi mbb130)  

This article is cited in 3 scientific papers (total in 3 papers)

Mathematical Modeling

Modular Modeling of the Human Cardiovascular System

I. N. Kiselevab, B. V. Semisalovab, E. A. Biberdorfc, R. N. Sharipovad, A. M. Blokhinc, F. A. Kolpakovba

a Institute of Systems Biology, Ltd
b Design Technological Institute of Digital Techniques SBRAS
c Sobolev Institute of Mathematics SBRAS
d Institute of Cytology and Genetics SBRAS

Abstract: We present a complex model of the human cardiovascular system (CVS) created by integration of several preexisted mathematical models, utilizing different formalisms: one-dimensional model of the human arterial system, a heart contraction model and a long-term kidney regulation model. Models integration was conducted with modular and agent-based modeling approaches applying. Those approaches were implemented as a plugin on the for BioUML — software for formal description and simulation of biological systems. The plugin allows graphical creation of agent-based models as modular diagrams comprising interconnected blocks (modules) and numerical simulation. All models were implemented in BioUML, adjusted and integrated in the complex model of the human CVS. The complex model was tested and preliminary results for a classic human CVS pathology were obtained. All models are available as a part of the BioUML software at www.biouml.org.

Key words: human cardiovascular system, arterial blood pressure regulation, kidney, modular modeling, agent-based modeling, numerical simulation, BioUML.

Full text: PDF file (1744 kB)
References: PDF file   HTML file
UDC: 51-76
Received 07.12.2012, Published 30.12.2012

Citation: I. N. Kiselev, B. V. Semisalov, E. A. Biberdorf, R. N. Sharipov, A. M. Blokhin, F. A. Kolpakov, “Modular Modeling of the Human Cardiovascular System”, Mat. Biolog. Bioinform., 7:2 (2012), 703–736

Citation in format AMSBIB
\Bibitem{KisSemBib12}
\by I.~N.~Kiselev, B.~V.~Semisalov, E.~A.~Biberdorf, R.~N.~Sharipov, A.~M.~Blokhin, F.~A.~Kolpakov
\paper Modular Modeling of the Human Cardiovascular System
\jour Mat. Biolog. Bioinform.
\yr 2012
\vol 7
\issue 2
\pages 703--736
\mathnet{http://mi.mathnet.ru/mbb130}


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    Citing articles on Google Scholar: Russian citations, English citations
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    This publication is cited in the following articles:
    1. A. A. Grinevich, A. V. Tankanag, N. K. Chemeris, “Issledovanie zavisimosti spektrov serdechnogo ritma cheloveka ot kontroliruemoi chastoty dykhaniya”, Matem. biologiya i bioinform., 8:2 (2013), 537–552  mathnet
    2. A. A. Grinevich, A. V. Tankanag, N. K. Chemeris, “Rol elastichnosti krovenosnykh sosudov v formirovanii vysokoamplitudnykh kolebanii krovotoka na chastote 0.1 Gts”, Matem. biologiya i bioinform., 9:2 (2014), 341–358  mathnet  crossref
    3. I. N. Kiselev, E. A. Biberdorf, V. I. Baranov, T. G. Komlyagina, V. N. Melnikov, I. Yu. Suvorova, S. G. Krivoschekov, F. A. Kolpakov, “Personalizatsiya parametrov i validatsiya modeli serdechno-sosudistoi sistemy cheloveka”, Matem. biologiya i bioinform., 10:2 (2015), 526–547  mathnet  crossref
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