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Mat. Biolog. Bioinform., 2018, Volume 13, Issue Suppl., Pages t39–t58 (Mi mbb362)  

Translations of Published Articles

Comparative analysis of amino acid sequences in particular domains of Hoc proteins in Teequatrovirinae subfamily bacteriophages

A. A. Zimina, G. V. Mikoulinskaiab, L. F. Nigmatullinaa, N. N. Nazipovac

a G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Pushchino, Moscow Region, Russia
b Branch of M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Pushchino, Moscow Region, Russia
c Institute of Mathematical Problems of Biology RAS – the Branch of Keldysh Institute of Applied Mathematics, Pushchino, Moscow Region, Russia

Abstract: The work presents the results of comparative research into immunoglobulinlike domains in the genomes of T4-related bacteriophages. Hoc proteins are proposed to be used for classification of the Teequatrovirinae phage subfamily. Particular domains in 31 Hoc proteins of the subfamily were subjected to phylogenetic analysis. The number of domains in Hoc proteins of different bacteriophages in the subfamily was shown to vary from one to five. Based on this, bacteriophages can be divided into six subgroups. The phylogenetic tree of the domains in hoc gene product proteins of T4-related bacteriophages forms three major branches. These are the branches of C-terminal, Nterminal and intermediate domains. The obligatory occurrence of the C-terminal domain in all Hoc proteins is indicative of its functional and structural significance for the formation of the protein and its attachment to phage’s capsid. Hypothetical schemes for the evolutionary origin of repeated amino acid sequences in Hoc proteins were formulated.

Key words: bacteriophage T4, Hoc protein, immunoglobulin-like proteins, domains, phylogenetic tree, protein evolution.

DOI: https://doi.org/10.17537/2018.13.t39

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UDC: 578.81, 51-76
Received 20.03.2018, Published 25.06.2018
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Citation: A. A. Zimin, G. V. Mikoulinskaia, L. F. Nigmatullina, N. N. Nazipova, “Comparative analysis of amino acid sequences in particular domains of Hoc proteins in Teequatrovirinae subfamily bacteriophages”, Mat. Biolog. Bioinform., 13, Suppl. (2018), t39–t58

Citation in format AMSBIB
\Bibitem{ZimMikNig18}
\by A.~A.~Zimin, G.~V.~Mikoulinskaia, L.~F.~Nigmatullina, N.~N.~Nazipova
\paper Comparative analysis of amino acid sequences in particular domains of Hoc proteins in \emph{Teequatrovirinae} subfamily bacteriophages
\jour Mat. Biolog. Bioinform.
\yr 2018
\vol 13
\pages t39--t58
\issueinfo Suppl.
\mathnet{http://mi.mathnet.ru/mbb362}
\crossref{https://doi.org/10.17537/2018.13.t39}


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