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Mat. Biolog. Bioinform., 2009, Volume 4, Issue 2, Pages 46–51 (Mi mbb44)  

This article is cited in 2 scientific papers (total in 2 papers)

Mathematical Modeling

On the possibility of superfast charge transfer in DNA

V. D. Lakhno, V. B. Sultanov

Institute of Mathematical Problems of Biology, Russian Academy of Sciences

Abstract: Numerous experiments on charge transfer in DNA yield a contradictory picture of the transfer: on the one hand they suggest that it is a very slow process and the charge is almost completely localized on one Watson–Crick pair, but on the other hand they demonstrate that the charge can travel a very large distance. To explain this contradiction we propose that superfast charge transitions are possible between base pairs on individual DNA fragments resulting in the establishment of a quasi-equilibrium charge distribution during the time less than that of charge solvation. In other words, we hypothesize these states irrespective of the nature of a mechanism responsible for their establishment, whether it be a hopping mechanism, or a band mechanism, or superexchange, or polaron transport, etc., leaving aside the debates of which one is more advantageous. We discuss qualitative differences between the charge transfer in a dry DNA and that in a solution. In a solution, of great importance is the charge solvation which decreases the transfer rate $10^7\div10^8$ times as compared with a dry DNA. We consider the conditions under which the superfast charge transfer in a DNA leading to quasiequilibrium distributions of polarons in a duplex is possible. Comparison of calculated quasi-equilibrium distributions with the experiment testifies to the possibility of superfast tunnel transitions of a hole in a DNA duplex in a solution.

Key words: Holstein Hamiltonian, hole, solvation.

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English version:
Mathematical Biology and Bioinformatics, 2009, 4:2, 1–6
UDC: 577, 51-7
Received 16.06.2009, Published 06.07.2009

Citation: V. D. Lakhno, V. B. Sultanov, “On the possibility of superfast charge transfer in DNA”, Mat. Biolog. Bioinform., 4:2 (2009), 46–51; Mat. Biolog. Bioinform., 4:2 (2009), 1–6

Citation in format AMSBIB
\by V.~D.~Lakhno, V.~B.~Sultanov
\paper On the possibility of superfast charge transfer in DNA
\jour Mat. Biolog. Bioinform.
\yr 2009
\vol 4
\issue 2
\pages 46--51
\jour Mat. Biolog. Bioinform.
\yr 2009
\vol 4
\issue 2
\pages 1--6

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    This publication is cited in the following articles:
    1. D. A. Tikhonov, E. V. Sobolev, V. D. Lakhno, N. S. Fialko, “Adiabaticheskoe priblizhenie pri raschetakh podvizhnosti zaryada v kholsteinovskoi modeli DNK”, Matem. biologiya i bioinform., 6:2 (2011), 264–272  mathnet
    2. Lakhno V.D., Fialko N.S., “Solvation Effects on Hole Mobility in the Poly G/Poly C Duplex”, Russ. J. Phys. Chem. A, 86:5 (2012), 832–836  crossref  isi  elib  elib  scopus
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