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Matem. Mod., 1993, Volume 5, Number 6, Pages 24–55 (Mi mm1981)  

This article is cited in 2 scientific papers (total in 2 papers)

Mathematical models and computer experiment

Investigation of the model of tRNA secondary structure folding process

N. N. Kozlov, E. I. Kugushev

M. V. Keldysh Institute for Applied Mathematics, Russian Academy of Sciences

Abstract: The results of computer simulation of RNA linear molecules folding into secondary structure are presented. The structure is formed in the course of two interacting processes: the molecular growth (sequential growth of the RNA molecular chain) and the structurization (gradual sequential secondary structure growth in the scope of developed molecular chain region). In the course of structurization the secondary structure develops through sequential addition of elementary substructures. In this case we have local minimization of free energy increment on a set of compatible stems. The calculation algorithms have been developed that caused the hundredfold increase of calculation speed. That algorithms use have made possible the structure folding investigation for full set of tRNA molecules, which was known in the world by the beginning of 1990. The solutions have been analysed on two-parameters region. Their assymmetry have been found with respect to the molecular chain growth direction. The greatest average percentage of tRNA secondary structure prediction (more than 86%) have been received for used free energy models.

Full text: PDF file (3658 kB)

Bibliographic databases:
UDC: 519.6.575
Received: 30.07.1992

Citation: N. N. Kozlov, E. I. Kugushev, “Investigation of the model of tRNA secondary structure folding process”, Matem. Mod., 5:6 (1993), 24–55

Citation in format AMSBIB
\Bibitem{KozKug93}
\by N.~N.~Kozlov, E.~I.~Kugushev
\paper Investigation of the model of tRNA secondary structure folding process
\jour Matem. Mod.
\yr 1993
\vol 5
\issue 6
\pages 24--55
\mathnet{http://mi.mathnet.ru/mm1981}
\zmath{https://zbmath.org/?q=an:1003.92510}


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    Citing articles on Google Scholar: Russian citations, English citations
    Related articles on Google Scholar: Russian articles, English articles

    This publication is cited in the following articles:
    1. N. N. Kozlov, “Odin sposob khraneniya geneticheskoi informatsii”, Matem. modelirovanie, 14:8 (2002), 72–78  mathnet  zmath
    2. N. N. Kozlov, “Integral characteristics of the genetic code”, Math. Models Comput. Simul., 3:2 (2011), 123–134  mathnet  crossref  mathscinet
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