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Kvantovaya Elektronika, 2014, Volume 44, Number 8, Pages 740–745 (Mi qe16020)  

This article is cited in 9 scientific papers (total in 9 papers)

Laser biophotonics

Volumetric cutaneous microangiography of human skin in vivo by VCSEL swept-source optical coherence tomography

Woo June Choi, R. K. Wang

University of Washington, Department of Bioengineering, Seattle, USA

Abstract: We demonstrate volumetric cutaneous microangiography of the human skin in vivo that utilises 1.3-μm high-speed sweptsource optical coherence tomography (SS-OCT). The swept source is based on a micro-electro-mechanical (MEMS)-tunable vertical cavity surface emission laser (VCSEL) that is advantageous in terms of long coherence length over 50 mm and 100 nm spectral bandwidth, which enables the visualisation of microstructures within a few mm from the skin surface. We show that the skin microvasculature can be delineated in 3D SS-OCT images using ultrahigh-sensitive optical microangiography (UHS-OMAG) with a correlation mapping mask, providing a contrast enhanced blood perfusion map with capillary flow sensitivity. 3D microangiograms of a healthy human finger are shown with distinct cutaneous vessel architectures from different dermal layers and even within hypodermis. These findings suggest that the OCT microangiography could be a beneficial biomedical assay to assess cutaneous vascular functions in clinic.

Keywords: cutaneous microcirculation, swept-source optical coherence tomography, vertical cavity surface emission laser, ultrahighsensitive optical microangiography, correlation mapping optical coherence tomography.

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English version:
Quantum Electronics, 2014, 44:8, 740–745

Bibliographic databases:

PACS: 42.30.Wb, 42.55.Px, 87.57.Q-
Received: 30.03.2014
Revised: 15.06.2014

Citation: Woo June Choi, R. K. Wang, “Volumetric cutaneous microangiography of human skin in vivo by VCSEL swept-source optical coherence tomography”, Kvantovaya Elektronika, 44:8 (2014), 740–745 [Quantum Electron., 44:8 (2014), 740–745]

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    Citing articles on Google Scholar: Russian citations, English citations
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    This publication is cited in the following articles:
    1. Lal C., Leahy M.J., Microcirculation, 23:5, SI (2016), 345–363  crossref  isi  scopus
    2. E. Li, Sh. Makita, Y.-J. Hong, D. Kasaragod, Y. Yasuno, Biomed. Opt. Express, 8:3 (2017), 1290–1305  crossref  isi  scopus
    3. S. J. Men, C.-L. Chen, W. Wei, T.-Y. Lai, S. Z. Song, R. K. Wang, Skin Res. Technol., 23:4 (2017), 607–612  crossref  isi  scopus
    4. A. Camino, Ya. Jia, G. Liu, J. Wang, D. Huang, Biomed. Opt. Express, 8:6 (2017), 3053–3066  crossref  isi  scopus
    5. J. Aguirre, B. Hindelang, A. Berezhnoi, U. Darsow, F. Lauffer, K. Eyerich, T. Biedermann, V. Ntziachristos, Photoacoustics, 10 (2018), 31–37  crossref  isi  scopus
    6. A. J. Deegan, R. K. Wang, Phys. Med. Biol., 64:7 (2019), 07TR01  crossref  isi  scopus
    7. J. Liu, N. Ding, Ya. Yu, L. Liu, X. Yuan, H. Lv, Yu. Zhao, Zh. Ma, J. Biophotonics, 12:10 (2019), UNSP e201900122  crossref  isi  scopus
    8. J. Liu, Ya. Li, Ya. Yu, X. Yuan, H. Lv, Yu. Zhao, Zh. Maa, Neurophotonics, 6:4 (2019), 045007  crossref  isi  scopus
    9. Y. Wang, Y. Hu, B. Peng, H. Zhou, Yu. Zhao, Zh. Ma, Biomed. Opt. Express, 11:1 (2020), 505–516  crossref  isi  scopus
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