Phosphorylated Derivatives of Alkaloids and Nitrogen-containing Heterocycles – Cholinesterase Inhibitors
A. S. Sadykova, D. N. Dalimova, N. N. Godovikovb
a Institute of Bioorganic Chemistry UzSSR, Tashkent
b A. N. Nesmeyanov Institute of Organoelement Compounds, USSR Academy of Sciences, Moscow
The review deals with the synthesis and anticholinesterase activities of phosphorylated derivatives of certain alkaloids and nitrogen-containing heterocycles. It is shown that the conformational properties of the alkaloid and nitrogen-containing heterocycle residues in the composition of the organophosphorus inhibitor (OPI) molecule play an important role in the inhibition of the catalytic activity of cholinesterases. The type of inhibition of cholinesterases also varies as a function of chemical structure.
The bibliography includes 45 references.
Russian Chemical Reviews, 1983, 52:10, 918–930
A. S. Sadykov, D. N. Dalimov, N. N. Godovikov, “Phosphorylated Derivatives of Alkaloids and Nitrogen-containing Heterocycles – Cholinesterase Inhibitors”, Usp. Khim., 52:10 (1983), 1602–1623; Russian Chem. Reviews, 52:10 (1983), 918–930
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