This article is cited in 2 scientific papers (total in 2 papers)
Structure and biological activity of endogenous and synthetic agonists of GPR119
I. N. Tyurenkov, A. A. Ozerov, D. V. Kurkin, E. O. Logvinova, D. A. Bakulin, E. V. Volotova, D. D. Borodin
Volgograd State Medical University
A G-protein-coupled receptor, GPR119, is a promising pharmacological target for a new class of hypoglycaemic drugs with an original mechanism of action, namely, increase in the glucose-dependent incretin and insulin secretion. In 2005, the first ligands were found and in the subsequent years, a large number of GPR119 agonists were synthesized in laboratories in various countries; the safest and most promising agonists have entered phase I and II clinical trials as agents for the treatment of type 2 diabetes mellitus and obesity. The review describes the major endogenous GPR119 agonists and the main trends in the design and modification of synthetic structures for increasing the hypoglycaemic activity. The data on synthetic agonists are arranged according to the type of the central core of the molecules.
The bibliography includes 104 references.
Russian Chemical Reviews, 2018, 87:2, 151–166
I. N. Tyurenkov, A. A. Ozerov, D. V. Kurkin, E. O. Logvinova, D. A. Bakulin, E. V. Volotova, D. D. Borodin, “Structure and biological activity of endogenous and synthetic agonists of GPR119”, Usp. Khim., 87:2 (2018), 151–166; Russian Chem. Reviews, 87:2 (2018), 151–166
Citation in format AMSBIB
\by I.~N.~Tyurenkov, A.~A.~Ozerov, D.~V.~Kurkin, E.~O.~Logvinova, D.~A.~Bakulin, E.~V.~Volotova, D.~D.~Borodin
\paper Structure and biological activity of endogenous and synthetic agonists of GPR119
\jour Usp. Khim.
\jour Russian Chem. Reviews
Citing articles on Google Scholar:
Related articles on Google Scholar:
This publication is cited in the following articles:
Tyurenkov I.N., Kurkin D.V., Bakulin D.A., Volotova E.V., Morkovin E.I., Chafeev M.A., Karapetian R.N., “Chemistry and Hypoglycemic Activity of Gpr119 Agonist Zb-16”, Front. Endocrinol., 9 (2018), 543
Ding Ya., Li Y., Chen Q., Niu B., “Advances in Antidiabetic Drugs Targeting Insulin Secretion”, Curr. Pharm. Design, 24:34 (2018), 3990–3997
|Number of views:|