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Usp. Khim., 2018, Volume 87, Issue 4, Pages 350–373 (Mi rcr4207)  

This article is cited in 1 scientific paper (total in 1 paper)

$^{18}\mathrm{F}$-Labelled catecholamine type radiopharmaceuticals in the diagnosis of neurodegenerative diseases and neuroendocrine tumours: approaches to synthesis and development prospects

S. Z. Vatsadze, O. E. Eremina, I. A. Veselova, S. N. Kalmykov, V. G. Nenajdenko

Lomonosov Moscow State University, Faculty of Chemistry

Abstract: The pathogenesis of many socially significant diseases such as neurodegenerative dementias and neuroendocrine tumours involves imbalance of neurotransmitters. Among the known neuroimaging methods, positron emission tomography (PET) is the most perfect and informative technique for diagnosing these diseases. The potential of PET is largely determined by the inventory of available radiopharmaceuticals, that is, biologically active molecules containing short-lived nuclides with positron decay. This review gives a systematic account of the application of fluorine-18-labelled catecholamine type radiopharmaceuticals in clinical investigations of the sympathetic and central nervous systems. The methods for the synthesis of these agents and existing problems are considered. The material is arranged according to the mechanisms of reactions that underlie the synthetic approaches: electrophilic, nucleophilic and metal-catalyzed reactions.
The bibliography includes 198 references.

Funding Agency Grant Number
Russian Science Foundation 16-13-00114


Full text: http://www.uspkhim.ru/.../paper_rus.phtml?journal_id=rc&paper_id=4752

English version:
Russian Chemical Reviews, 2018, 87:4, 350–373

Bibliographic databases:

Document Type: Article
Received: 23.05.2017

Citation: S. Z. Vatsadze, O. E. Eremina, I. A. Veselova, S. N. Kalmykov, V. G. Nenajdenko, “$^{18}\mathrm{F}$-Labelled catecholamine type radiopharmaceuticals in the diagnosis of neurodegenerative diseases and neuroendocrine tumours: approaches to synthesis and development prospects”, Usp. Khim., 87:4 (2018), 350–373; Russian Chem. Reviews, 87:4 (2018), 350–373

Citation in format AMSBIB
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\by S.~Z.~Vatsadze, O.~E.~Eremina, I.~A.~Veselova, S.~N.~Kalmykov, V.~G.~Nenajdenko
\paper $^{18}\mathrm{F}$-Labelled catecholamine type radiopharmaceuticals in the diagnosis of neurodegenerative diseases and neuroendocrine tumours: approaches to synthesis and development prospects
\jour Usp. Khim.
\yr 2018
\vol 87
\issue 4
\pages 350--373
\mathnet{http://mi.mathnet.ru/rcr4207}
\transl
\jour Russian Chem. Reviews
\yr 2018
\vol 87
\issue 4
\pages 350--373
\crossref{https://doi.org/10.1070/RCR4752}
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\scopus{http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85046554237}


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    This publication is cited in the following articles:
    1. Goodilin E.A. Semenova A.A. Eremina O.E. Brazhe N.A. Goodilina E.A. Danzanova T.Yu. Maksimov V G. Veselova I.A., “Promising Methods For Noninvasive Medical Diagnosis Based on the Use of Nanoparticles: Surface-Enhanced Raman Spectroscopy in the Study of Cells, Cell Organelles and Neurotransmitter Metabolism Markers”, Bull. Russ. State Med. Univ., 2018, no. 6, 62–73  crossref  isi
  • Успехи химии Russian Chemical Reviews
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