Purine derivatives with antituberculosis activity
D. A. Gruzdev, V. V. Musiyak, G. L. Levit, V. P. Krasnov, V. N. Charushin
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of Russian Academy of Sciences, Ekaterinburg
The review summarizes the data published over the last 10–15 years concerning the key groups of purine derivatives with antituberculosis activity. The structures of purines containing heteroatoms (S, O, N), fragments of heterocycles, amino acids and peptides, in the 6-position, as well as of purine nucleosides are presented. The possible targets for the action of such compounds and structure–activity relationship are discussed. Particular attention is paid to the most active compounds, which are of considerable interest as a basis for the development of efficient antituberculosis drugs.
The bibliography includes 99 references.
Russian Chemical Reviews, 2018, 87:6, 604–618
D. A. Gruzdev, V. V. Musiyak, G. L. Levit, V. P. Krasnov, V. N. Charushin, “Purine derivatives with antituberculosis activity”, Usp. Khim., 87:6 (2018), 604–618; Russian Chem. Reviews, 87:6 (2018), 604–618
Citation in format AMSBIB
\by D.~A.~Gruzdev, V.~V.~Musiyak, G.~L.~Levit, V.~P.~Krasnov, V.~N.~Charushin
\paper Purine derivatives with antituberculosis activity
\jour Usp. Khim.
\jour Russian Chem. Reviews
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