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TVT, 2019, Volume 57, Issue 5, Pages 764–768 (Mi tvt11087)  

Heat and Mass Transfer and Physical Gasdynamics

Production of lidocaine nanoforms via the rapid extension of a supercritical solution into water medium

I. V. Kuznetsova, I. I. Gil'mutdinov, I. M. Gil'mutdinov, A. N. Sabirzyanov

Kazan National Research Technological University

Abstract: The pharmaceutical substances of a group of local anesthetics, in particular, the drug lidocaine, are the object of the study. The influence of the thermodynamic parameters of the state on the process of lidocaine dispersion via the rapid expansion of a supercritical solution in an aqueous medium (RESAS) is studied in this work. The experiments were carried out at saturation temperatures of $40$ and $60^{\circ}$C, a temperature of the expansion device of $40^{\circ}$C, and a system pressure of $15$$35$ MPa. The structure of the obtained particles was analyzed with a D8 ADVANCE diffractometer (before and after grinding). The melting points of the initial and processed lidocaine substance were determined.

Funding Agency Grant Number
Russian Science Foundation 18-79-00064
The study was supported by the Russian Foundation for Basic Research, project no. 18-79-00064.

Author to whom correspondence should be addressed

DOI: https://doi.org/10.1134/S0040364419040136

Full text: PDF file (1965 kB)
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English version:
High Temperature, 2019, 57:5, 726–730

Bibliographic databases:

UDC: 533.1, 536.75
Received: 09.07.2018
Revised: 23.01.2019
Accepted:27.03.2019

Citation: I. V. Kuznetsova, I. I. Gil'mutdinov, I. M. Gil'mutdinov, A. N. Sabirzyanov, “Production of lidocaine nanoforms via the rapid extension of a supercritical solution into water medium”, TVT, 57:5 (2019), 764–768; High Temperature, 57:5 (2019), 726–730

Citation in format AMSBIB
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