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UFN, 2020, Volume 190, Number 7, Pages 749–761 (Mi ufn6748)  

This article is cited in 3 scientific papers (total in 5 papers)

PHYSICS OF OUR DAYS

Photon entanglement for life-science imaging: rethinking the limits of the possible

A. M. Zheltikovabcde*, M. O. Scullibfg

a International Laser Center, Lomonosov Moscow State University, Physics Department
b Institute for Quantum Science and Engineering, Department of Physics and Astronomy, Texas A&M University
c Russian Quantum Center, Skolkovo, Moscow region
d Tupolev Kazan National Research Technical University
e National Research Centre "Kurchatov Institute", Moscow
f Princeton University
g Baylor University

Abstract: Quantum entanglement is a powerful resource that revolutionizes information science, opens new horizons in communication technologies, and pushes the frontiers of sensing and imaging. Whether or not the methods of quantum entanglement can be extended to life-science imaging is far from clear. Live biological systems are eluding quantum-optical probes, proving, time and time again, too lossy, too noisy, too warm, and too wet to be meaningfully studied by quantum states of light. The central difficulty that puts the main roadblock on the path toward entanglement-enhanced nonlinear bioimaging is that the two-photon absorption (TPA) of entangled photons can exceed the TPA of uncorrelated photons only at the level of incident photon flux densities as low as one photon per entanglement area per entanglement time. This fundamental limitation has long been believed to rule out even a thinnest chance for a success of bioimaging with entangled photons. Here, we show that new approaches in nonlinear and quantum optics, combined with the latest achievements in biotechnologies, open the routes toward efficient photon-entanglement-based strategies in TPA microscopy that can help confront long-standing challenges in life-science imaging. Unleashing the full potential of this approach will require, however, high throughputs of virus-construct delivery, high expression efficiencies of genetically encodable fluorescent markers, high-brightness sources of entangled photons, as well as a thoughtful entanglement engineering in time, space, pulse, and polarization modes. We demonstrate that suitably tailored nonlinear optical fibers can deliver entangled photon pairs confined to entanglement volumes many orders of magnitude smaller than the entanglement volumes attainable through spontaneous parametric down-conversion. These ultracompact modes of entangled photons are shown to enable a radical enhancement of the TPA of entangled photons, opening new avenues for quantum entanglement in life-science imaging.

Funding Agency Grant Number
Russian Foundation for Basic Research 17-00-00212
19-02-00473
18-29-20031
18-52-00025
Фонд Уелча А-1801-20180324
Ministry of Science and Higher Education of the Russian Federation 14.Z50.31.0040
Russian Science Foundation 20-12-00088
This research was supported in part by the Russian Foundation for Basic Research (project no. 17-00-00212, 19-02-00473, 18-29-20031, and 18-52-00025) and Welch Foundation (Grant no. A-1801-20180324). Research into multioctave nonlinear optics is supported by Russian Science Foundation (project no. 20-12-00088).

* Author to whom correspondence should be addressed

DOI: https://doi.org/10.3367/UFNr.2020.03.038743

Full text: PDF file (839 kB)
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English version:
Physics–Uspekhi, 2020, 63:7, 698–707

Bibliographic databases:

PACS: 03.65.-w, 03.65.Ta, 03.65.Ud, 03.65.Yz, 03.67.-a, 32.80.Qk
Received: February 7, 2020
Accepted: March 25, 2020

Citation: A. M. Zheltikov, M. O. Sculli, “Photon entanglement for life-science imaging: rethinking the limits of the possible”, UFN, 190:7 (2020), 749–761; Phys. Usp., 63:7 (2020), 698–707

Citation in format AMSBIB
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\paper Photon entanglement for life-science imaging: rethinking the limits of the possible
\jour UFN
\yr 2020
\vol 190
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\pages 749--761
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\crossref{https://doi.org/10.3367/UFNr.2020.03.038743}
\elib{https://elibrary.ru/item.asp?id=45232312}
\transl
\jour Phys. Usp.
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\vol 63
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\pages 698--707
\crossref{https://doi.org/10.3367/UFNe.2020.03.038743}
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    2. A. V. Belinsky, “Wigner's friend paradox: does objective reality not exist?”, Phys. Usp., 63:12 (2020), 1256–1263  mathnet  crossref  crossref  isi  elib
    3. Fedotov V I., Yi Zh., Voronin A.A., Svidzinsky A.A., Sower K., Liu X., Vlasova E., Peng T., Liu X., Moiseev S.A., Belousov V.V., Sokolov V A., Scully M.O., Zheltikov A.M., “Light and Corona: Guided-Wave Readout For Coronavirus Spike Protein-Host-Receptor Binding”, Opt. Lett., 45:19 (2020), 5428–5431  crossref  isi  scopus
    4. Yu. N. Eroshenko, “Physics news on the Internet (based on electronic preprints)”, Phys. Usp., 64:7 (2021), 743–745  mathnet  crossref  crossref
    5. Yu. N. Eroshenko, “Physics news on the Internet (based on electronic preprints)”, Phys. Usp., 64:9 (2021), 964–965  mathnet  crossref  crossref  isi
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