Graphene-based biosensor: Biomolecules coupling in the de Jannes and Fröhlich models

A three-layer structure consisting of epitaxial graphene and two organic macromolecules: a biore-ceptor (antibody) deposited on graphene and a biomarker (antigen) in contact with it. Simple analytical estimates of antigen adhesion to antibody made within the framework of the de Gennes and Fröhlich models are presented. Numerical estimates have shown that the main mechanism for coupling of biomolecules is their stitching by monomeric macromolecule connector (de Jannes model).