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Fizika Tverdogo Tela, 2014, Volume 56, Issue 7, Pages 1292–1300 (Mi ftt12061)  
This article is cited in 23 scientific papers (total in 23 papers)

Magnetism

Single-domain magnetic nanoparticles in an alternating magnetic field as mediators of local deformation of the surrounding macromolecules

Yu.I. Golovinabc, S. L. Gribanovskiia, D. Yu. Golovina, N. L. Klyachkobc, A. V. Kabanovbc

a Research Institute "Nanotechnology and Nanomaterials", Tambov State University
b Lomonosov Moscow State University
c Center for Nanotechnology in Drug Delivery, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, USA
Full-text PDF (732 kB) Citations (23)
Abstract: The forces, deformations, and stresses generated in macromolecules attached to single-domain magnetic nanoparticles under the influence of a low-frequency (nonheating) magnetic field have been analyzed analytically and numerically. It has been shown that, in bioactive macromolecules, an alternating magnetic field with an induction of 0.1–1.0 T and a circular frequency of $\lesssim$ 10$^4$ s$^{-1}$ can induce forces up to several hundred piconewtons, absolute deformations up to a few tens of nanometers, as well as compressive and shear stresses exceeding 10$^7$ Pa. These mechanical stimuli are sufficient for a significant change of interatomic distances in active centers, conformation of macromolecules, and even a breaking of some bonds, which makes it possible to develop a new technological platform for targeted delivery of drugs, remote control of their activity, and cancer-cell destruction.
Received: 21.01.2014
English version:
Physics of the Solid State, 2014, Volume 56, Issue 7, Pages 1342–1351
DOI: https://doi.org/10.1134/S1063783414070142
Bibliographic databases:
Document Type: Article
Language: Russian
Citation: Yu.I. Golovin, S. L. Gribanovskii, D. Yu. Golovin, N. L. Klyachko, A. V. Kabanov, “Single-domain magnetic nanoparticles in an alternating magnetic field as mediators of local deformation of the surrounding macromolecules”, Fizika Tverdogo Tela, 56:7 (2014), 1292–1300; Phys. Solid State, 56:7 (2014), 1342–1351
Citation in format AMSBIB
\Bibitem{GolGriGol14}
\by Yu.I.~Golovin, S.~L.~Gribanovskii, D.~Yu.~Golovin, N.~L.~Klyachko, A.~V.~Kabanov
\paper Single-domain magnetic nanoparticles in an alternating magnetic field as mediators of local deformation of the surrounding macromolecules
\jour Fizika Tverdogo Tela
\yr 2014
\vol 56
\issue 7
\pages 1292--1300
\mathnet{http://mi.mathnet.ru/ftt12061}
\elib{https://elibrary.ru/item.asp?id=22019115}
\transl
\jour Phys. Solid State
\yr 2014
\vol 56
\issue 7
\pages 1342--1351
\crossref{https://doi.org/10.1134/S1063783414070142}
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  • https://www.mathnet.ru/eng/ftt/v56/i7/p1292
    • This publication is cited in the following 23 articles:
    Citing articles in Google Scholar: Russian citations, English citations
    Related articles in Google Scholar: Russian articles, English articles
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