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Izvestiya of Saratov University. Physics, 2011, Volume 11, Issue 2, Pages 54–57
DOI: https://doi.org/10.18500/1817-3020-2011-11-2-54-57
(Mi isuph115)
 

Physics

The changes of morphological indicators of bone marrow and peripheral blood at long exposure of gold nanoparticles

S. S. Firsovaa, A. B. Bucharskayaa, G. N. Maslyakovaa, O. V. Zlobinaa, O. V. Matveevaa, I. O. Bugaevaa, N. G. Khlebtsovb, B. N. Khlebtsovb, V. A. Bogatyrevb

a Saratov State Medical University named after V. I. Razumovsky
b Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences, Saratov
References:
Abstract: The exposure of gold nanoparticles with different size on the morphological indicators of red bone marrow and peripheral blood of white not purebred rats at long peroral introduction were studied in experiment. The mutagen influence of gold nanoparticles on polychromatophilous erythrocytes of bone marrow were estimated by micronuclear test. During research the reduction of quantity of leukocytes in peripheral blood and the erythrocyte volume reduction with increase of their hemoglobin saturation were revealed. The changes reflecting the mutagen activity of gold nanoparticles were not revealed at carrying out micronuclear test. The changes of morphological indicators of bone marrow testify about stimulation processes occurring in a marrow lymphocytic and myelocytic sprouts of hemopoiesis as a result of reduction of mature cells in peripheral blood.
Keywords: gold nanoparticles, peripheral blood, red bone marrow.
Document Type: Article
Language: Russian
Citation: S. S. Firsova, A. B. Bucharskaya, G. N. Maslyakova, O. V. Zlobina, O. V. Matveeva, I. O. Bugaeva, N. G. Khlebtsov, B. N. Khlebtsov, V. A. Bogatyrev, “The changes of morphological indicators of bone marrow and peripheral blood at long exposure of gold nanoparticles”, Izv. Sarat. Univ. Physics, 11:2 (2011), 54–57
Citation in format AMSBIB
\Bibitem{FirBucMas11}
\by S.~S.~Firsova, A.~B.~Bucharskaya, G.~N.~Maslyakova, O.~V.~Zlobina, O.~V.~Matveeva, I.~O.~Bugaeva, N.~G.~Khlebtsov, B.~N.~Khlebtsov, V.~A.~Bogatyrev
\paper The changes of morphological indicators of bone marrow and peripheral blood at long exposure of gold nanoparticles
\jour Izv. Sarat. Univ. Physics
\yr 2011
\vol 11
\issue 2
\pages 54--57
\mathnet{http://mi.mathnet.ru/isuph115}
\crossref{https://doi.org/10.18500/1817-3020-2011-11-2-54-57}
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