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Izvestiya of Saratov University. Physics, 2015, Volume 15, Issue 4, Pages 22–27
DOI: https://doi.org/10.18500/1817-3020-2015-15-4-22-27 (Mi isuph247) 		 
Physics

Morphological changes in transplanted sarcoma S45 at photodynamic therapy using nanocomposites based on gold nanorods

A. B. Bucharskayaa, È. A. Geninabc, A. N. Bashkatovbc, G. S. Terentyuka, N. A. Navolokina, G. N. Maslyakovaa, N. G. Khlebtsovd, B. N. Khlebtsovd, V. V. Tuchinbce

a Saratov State Medical University named after V. I. Razumovsky
b Saratov State University
c Tomsk State University
d Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences, Saratov
e Institute of Precision Mechanics and Control, Russian Academy of Sciences, Saratov
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DOI: https://doi.org/10.18500/1817-3020-2015-15-4-22-27
Abstract: Photodynamic therapy (PDT) of cancer is an advanced application of gold nanostructures. The purpose of the research is to study the morphological changes in the transplanted sarcoma S45 at PDT using nanocomposites based on gold nanorods (GNRs). GNRs synthesized with the germ method and covered by a silicon coating, functionalized by hematoporphyrin, were intratumorally injected in rats with transplanted sarcoma S45. The tumor was irradiated by He-Ne laser with a wavelength of 632.8 nm. A day later, the animals were withdrawn from the experiment, and the tumor tissue was sampled for morphological studies. After PDT, expressed necrobiotic changes on the background of the inflammatory reaction were observed in transplanted tumors.
Keywords: gold nanorods, photodynamic therapy, transplanted sarcoma S45.
Funding agency Grant number
Russian Science Foundation 14-13-01167
14-15-00186
Document Type: Article
UDC: 616-006.04; 616-018; 535.361; 53.06
Language: Russian
Citation: A. B. Bucharskaya, È. A. Genina, A. N. Bashkatov, G. S. Terentyuk, N. A. Navolokin, G. N. Maslyakova, N. G. Khlebtsov, B. N. Khlebtsov, V. V. Tuchin, “Morphological changes in transplanted sarcoma S45 at photodynamic therapy using nanocomposites based on gold nanorods”, Izv. Sarat. Univ. Physics, 15:4 (2015), 22–27
Citation in format AMSBIB
\Bibitem{BucGenBas15}
\by A.~B.~Bucharskaya, \`E.~A.~Genina, A.~N.~Bashkatov, G.~S.~Terentyuk, N.~A.~Navolokin, G.~N.~Maslyakova, N.~G.~Khlebtsov, B.~N.~Khlebtsov, V.~V.~Tuchin
\paper Morphological changes in transplanted sarcoma S45 at photodynamic therapy using nanocomposites based on gold nanorods
\jour Izv. Sarat. Univ. Physics
\yr 2015
\vol 15
\issue 4
\pages 22--27
\mathnet{http://mi.mathnet.ru/isuph247}
\crossref{https://doi.org/10.18500/1817-3020-2015-15-4-22-27}
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