M. G. Kasparavichius, D. I. Weber, A. S. Bunev, A. V. Sapegin, “Novel 2-amino-substituted (thio)morpholine-3,5-diones: synthesis and cytotoxicity studies”, Mendeleev Commun., 34:2 (2024), 262

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Mendeleev Communications, 2024, Volume 34, Issue 2, Pages 262–264
DOI: https://doi.org/10.1016/j.mencom.2024.02.032 (Mi mendc101)

This article is cited in 1 scientific paper (total in 1 paper)

Communications

Novel 2-amino-substituted (thio)morpholine-3,5-diones: synthesis and cytotoxicity studies

M. G. Kasparavichius^a, D. I. Weber^a, A. S. Bunev^ab, A. V. Sapegin^a

^a Institute of Chemistry, St. Petersburg State University, St. Petersburg, Russian Federation
^b Medicinal Chemistry Centre, Togliatti State University, Togliatti, Russian Federation

Full-text PDF (230 kB) Citations (1) Supplementary materials

DOI: https://doi.org/10.1016/j.mencom.2024.02.032

Graphic abstract: Novel 2-amino-substituted (thio)morpholine-3,5-diones: synthesis and cytotoxicity studies

Abstract: The present study explores the synthesis of new potential Cereblon ligands, 2-amino derivatives of (thio)morpholine-3,5-diones. The resulting compounds demonstrate notable cytotoxic effects in tests conducted in vitro on myeloma cell lines, highlighting the potential of these compounds as molecular glues.

Keywords: thiomorpholine-3,5-dione, morpholine-3,5-dione, amines, halogenation, nucleophilic substitution reaction, cytotoxicity studies, immunomodulatory drugs, Cereblon.

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Document Type: Article

Language: English

*Supplementary materials:*
		Supplementary_data_1.pdf	(2.0 Mb)

Citation: M. G. Kasparavichius, D. I. Weber, A. S. Bunev, A. V. Sapegin, “Novel 2-amino-substituted (thio)morpholine-3,5-diones: synthesis and cytotoxicity studies”, Mendeleev Commun., 34:2 (2024), 262–264

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