A. R. Tsygankova, D. A. Gruzdev, V. V. Kanygin, T. Ya. Guselnikova, A. A. Telegina, A. I. Kasatova, A. I. Kichigin, G. L. Levit, L. V. Mechetina, R. A. Mukhamadiyarov, I. A. Razumov, O. I. Solovieva, O. Yu. Volkova, A. A. Ponomarev, V. P. Krasnov, E. L. Zavjalov, “Liposomes loaded with lipophilic derivative of closo-carborane as a potential boron delivery system for boron neutron capture therapy of tumors”, Mendeleev Commun., 31:5 (2021), 659

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Mendeleev Communications, 2021, Volume 31, Issue 5, Pages 659–661
DOI: https://doi.org/10.1016/j.mencom.2021.09.022 (Mi mendc1014)

This article is cited in 10 scientific papers (total in 10 papers)

Communications

Liposomes loaded with lipophilic derivative of closo-carborane as a potential boron delivery system for boron neutron capture therapy of tumors

A. R. Tsygankova^ab, D. A. Gruzdev^cd, V. V. Kanygin^a, T. Ya. Guselnikova^ab, A. A. Telegina^cd, A. I. Kasatova^ae, A. I. Kichigin^a, G. L. Levit^c, L. V. Mechetina^f, R. A. Mukhamadiyarov^g, I. A. Razumov^ah, O. I. Solovieva^h, O. Yu. Volkova^f, A. A. Ponomarev^h, V. P. Krasnov^cd, E. L. Zavjalov^ah

^a Novosibirsk State University, Novosibirsk, Russian Federation
^b A.V. Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation
^c I.Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russian Federation
^d Institute of Chemical Engineering, Ural Federal University, Ekaterinburg, Russian Federation
^e G.I. Budker Institute of Nuclear Physics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation
^f Institute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation
^g Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation
^h Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation

Full-text PDF (733 kB) Citations (10) Supplementary materials

DOI: https://doi.org/10.1016/j.mencom.2021.09.022

Graphic abstract: Liposomes loaded with lipophilic derivative of closo-carborane as a potential boron delivery system for boron neutron capture therapy of tumors

Abstract: Liposomes encapsulated with lipophilic derivative of 1,2-dicarba-closo-dodecaborane have been obtained and tested for toxicity to glioblastoma U87 cells and biodistribution on a U87MG xenograft mouse model. The liposomes are able to penetrate the tumor and provide boron concentration up to 1.5 mmmmg g–1 with tumor-to-muscle ratio up to 2.4.

Keywords: amide, closo-carborane, liposomes, U87 tumor model, toxicity, biodistribution, BNCT.

Bibliographic databases:

Document Type: Article

Language: English

*Supplementary materials:*
		Supplementary_data_1.pdf	(371.2 Kb)

Citation: A. R. Tsygankova, D. A. Gruzdev, V. V. Kanygin, T. Ya. Guselnikova, A. A. Telegina, A. I. Kasatova, A. I. Kichigin, G. L. Levit, L. V. Mechetina, R. A. Mukhamadiyarov, I. A. Razumov, O. I. Solovieva, O. Yu. Volkova, A. A. Ponomarev, V. P. Krasnov, E. L. Zavjalov, “Liposomes loaded with lipophilic derivative of closo-carborane as a potential boron delivery system for boron neutron capture therapy of tumors”, Mendeleev Commun., 31:5 (2021), 659–661

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https://www.mathnet.ru/eng/mendc/v31/i5/p659

This publication is cited in the following 10 articles:

Citing articles in Google Scholar: Russian citations, English citations
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