Abstract:
Hybrids composed of 3-pentylnorbornadiene-2-carboxylic acid or its quadricyclane isomer molecules linked to methano-C60 fullerene via triethylene glycol spacer were synthesized by the Bingel–Hirsch reaction. The quadricyclane derivative possesses markedly higher apoptosis-inducing activity against the Jurkat tumor cells than the norbornadiene one.
Citation:
U. M. Dzhemilev, A. R. Akhmetov, V. A. D'yakonov, L. U. Dzhemileva, M. M. Yunusbaeva, A. R. Tuktarov, “Synthesis and antitumor activity of methanofullerenes equipped with norbornadiene and quadricyclane moieties”, Mendeleev Commun., 30:2 (2020), 150–152
Linking options:
https://www.mathnet.ru/eng/mendc1130
https://www.mathnet.ru/eng/mendc/v30/i2/p150
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