A. N. Vereshchagin, N. A. Frolov, V. Yu. Konyuhova, E. O. Dorofeeva, K. A. Hansford, M. P. Egorov, “Synthesis and biological evaluation of novel bis-quaternary ammonium compounds with p-terphenyl spacer”, Mendeleev Commun., 30:4 (2020), 424

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Mendeleev Communications, 2020, Volume 30, Issue 4, Pages 424–426
DOI: https://doi.org/10.1016/j.mencom.2020.07.006 (Mi mendc1211)

This article is cited in 19 scientific papers (total in 19 papers)

Communications

Synthesis and biological evaluation of novel bis-quaternary ammonium compounds with p-terphenyl spacer

A. N. Vereshchagin^a, N. A. Frolov^a, V. Yu. Konyuhova^a, E. O. Dorofeeva^a, K. A. Hansford^b, M. P. Egorov^a

^a N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^b Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia

Full-text PDF (190 kB) Citations (19) Supplementary materials

DOI: https://doi.org/10.1016/j.mencom.2020.07.006

Graphic abstract: Synthesis and biological evaluation of novel bis-quaternary ammonium compounds with <i>p</i>-terphenyl spacer

Abstract: Novel bis-quaternary ammonium compounds with a p-terphenyl spacer between two pyridinium heads were synthesized. Hit compound with C₈H₁₇ aliphatic substituent is superior to known benzalkonium chloride, miramistin and chlorhexidine bisgluconate in MIC values against five pathogenic bacteria.

Keywords: bis-quaternary ammonium compounds, pyridinium salts, terphenyls, alkylation, antibacterial agents, fungicides, antifungal activity, methicillin resistance, Staphylococcus aureus.

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Document Type: Article

Language: English

*Supplementary materials:*
		Supplementary_data_1.pdf	(2.1 Mb)

Citation: A. N. Vereshchagin, N. A. Frolov, V. Yu. Konyuhova, E. O. Dorofeeva, K. A. Hansford, M. P. Egorov, “Synthesis and biological evaluation of novel bis-quaternary ammonium compounds with p-terphenyl spacer”, Mendeleev Commun., 30:4 (2020), 424–426

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https://www.mathnet.ru/eng/mendc1211

https://www.mathnet.ru/eng/mendc/v30/i4/p424

This publication is cited in the following 19 articles:

Citing articles in Google Scholar: Russian citations, English citations
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