aDepartment of Chemistry, Baku State University, Baku, Azerbaijan bDepartment of Chemistry and Molecular Biology and the Center for Antibiotic Resistance Research (CARe), University of Gothenburg, Gothenburg, Sweden cDepartment of Chemistry, Uppsala University, Uppsala, Sweden
Abstract:
New 2-amino-4-aryl-3-cyanopyridines were obtained by the three-component condensation of arylidenemalononitriles, malononitrile and (di)amine system or acetoacetanilide. Antibacterial activity of all synthesized compounds against the Gram-negative bacteria E. coli and the Gram-positive B. subtilis was tested, the only representative showed a substantial antimicrobial effect.
Keywords:
3,5-dicyanopyridines, antimicrobial activity, halogen bonding, bacteria, E. coli, B. subtilis.
Citation:
I. G. Mamedov, F. N. Naghiev, A. M. Maharramov, O. Uwangue, A. Farewell, P. Sunnerhagen, M. Erdelyi, “Antibacterial activity of 2-amino-3-cyanopyridine derivatives”, Mendeleev Commun., 30:4 (2020), 498–499
Linking options:
https://www.mathnet.ru/eng/mendc1236
https://www.mathnet.ru/eng/mendc/v30/i4/p498
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