M. P. Paramonova, R. Snoeck, G. Andrei, A. L. Khandazhinskaya, M. S. Novikov, “New acetamide derivatives containing (ω-p-bromophenoxyalkyl)uracil moiety and their anticytomegalovirus activity”, Mendeleev Commun., 30:5 (2020), 602

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Mendeleev Communications, 2020, Volume 30, Issue 5, Pages 602–603
DOI: https://doi.org/10.1016/j.mencom.2020.09.016 (Mi mendc1265)

This article is cited in 9 scientific papers (total in 9 papers)

Communications

New acetamide derivatives containing (ω-p-bromophenoxyalkyl)uracil moiety and their anticytomegalovirus activity

M. P. Paramonova^a, R. Snoeck^b, G. Andrei^b, A. L. Khandazhinskaya^c, M. S. Novikov^a

^a Volgograd State Medical University, Volgograd, Russian Federation
^b Rega Institute for Medical Research, Leuven, Belgium
^c V.A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russian Federation

Full-text PDF (161 kB) Citations (9) Supplementary materials

DOI: https://doi.org/10.1016/j.mencom.2020.09.016

Graphic abstract: New acetamide derivatives containing (ω-p-bromophenoxyalkyl)uracil moiety and their anticytomegalovirus activity

Abstract: New N-aryl-2-{3-[ω-(4-bromophenoxy)alkyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}acetamides have been obtained from 1-[ω-(4-bromophenoxy)alkyl]uracil and 2-chloro-N-(4-phenoxyphenyl)acetamide derivatives. Investigation of their antiviral properties against human cytomegalovirus revealed that the representative with dodecane-1,12-diyl linker exhibited powerful virus inhibitory activity in vitro.

Keywords: human cytomegalovirus, uracil derivative, acetamide, diaryl oxide, bromoarene, antiviral activity.

Bibliographic databases:

Document Type: Article

Language: English

*Supplementary materials:*
		Supplementary_data_1.pdf	(1.6 Mb)

Citation: M. P. Paramonova, R. Snoeck, G. Andrei, A. L. Khandazhinskaya, M. S. Novikov, “New acetamide derivatives containing (ω-p-bromophenoxyalkyl)uracil moiety and their anticytomegalovirus activity”, Mendeleev Commun., 30:5 (2020), 602–603

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https://www.mathnet.ru/eng/mendc1265

https://www.mathnet.ru/eng/mendc/v30/i5/p602

This publication is cited in the following 9 articles:

Citing articles in Google Scholar: Russian citations, English citations
Related articles in Google Scholar: Russian articles, English articles

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