M. I. Savchuk, I. S. Kovalev, V. L. Rusinov, D. S. Kopchuk, A. P. Krinochkin, G. V. Zyryanov, O. N. Chupakhin, V. N. Charushin, “Rapid metal free construction of 3-positioned 2-pyridyl substituent in indoles”, Mendeleev Commun., 30:6 (2020), 712

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Mendeleev Communications, 2020, Volume 30, Issue 6, Pages 712–713
DOI: https://doi.org/10.1016/j.mencom.2020.11.007 (Mi mendc1300)

This article is cited in 7 scientific papers (total in 7 papers)

Communications

Rapid metal free construction of 3-positioned 2-pyridyl substituent in indoles

M. I. Savchuk^a, I. S. Kovalev^a, V. L. Rusinov^ab, D. S. Kopchuk^ab, A. P. Krinochkin^ab, G. V. Zyryanov^ab, O. N. Chupakhin^ab, V. N. Charushin^ab

^a Institute of Chemical Engineering, Ural Federal University, Ekaterinburg, Russian Federation
^b I.Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russian Federation

Full-text PDF (206 kB) Citations (7) Supplementary materials

DOI: https://doi.org/10.1016/j.mencom.2020.11.007

Graphic abstract: Rapid metal free construction of 3-positioned 2-pyridyl substituent in indoles

Abstract: New access to substituted 2-(indol-3-yl)pyridines involves two stage protocol, namely, a reaction of deoxygenative nucleophilic substitution of hydrogen in 1,2,4-triazine-4-oxides under the action of indoles followed by aza-Diels–Alder reaction of thus obtained 5-indolyl-1,2,4-triazines with 2,5-norbornadiene in a pressure vessel. The reactions sequence provides good yields and is suitable for wide scope of substituted 1,2,4-triazines.

Keywords: 2-(indol-3-yl)pyridines, nucleophilic substitution of hydrogen, aza-Diels–Alder reaction, 1,2,4-triazines, pyridines.

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Document Type: Article

Language: English

*Supplementary materials:*
		Supplementary_data_1.pdf	(6.1 Mb)

Citation: M. I. Savchuk, I. S. Kovalev, V. L. Rusinov, D. S. Kopchuk, A. P. Krinochkin, G. V. Zyryanov, O. N. Chupakhin, V. N. Charushin, “Rapid metal free construction of 3-positioned 2-pyridyl substituent in indoles”, Mendeleev Commun., 30:6 (2020), 712–713

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https://www.mathnet.ru/eng/mendc1300

https://www.mathnet.ru/eng/mendc/v30/i6/p712

This publication is cited in the following 7 articles:

Citing articles in Google Scholar: Russian citations, English citations
Related articles in Google Scholar: Russian articles, English articles

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