D. N. Pelageev, S. M. Kovach, N. N. Balaneva, Yu. E. Sabutski, K. L. Borisova, E. S. Menchinskaya, E. A. Chingizova, A. R. Chingizov, A. L. Burylova, O. Yu. Slabko, K. A. Drozdov, V. Ph. Anufriev, “Synthesis and biological activity of thiazole–carbohydrate conjugates based on thiacarpine, an analogue of the cytotoxic alkaloid from the ascidian Polycarpa aurata”, Mendeleev Commun., 35:1 (2025), 66

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Mendeleev Communications, 2025, Volume 35, Issue 1, Pages 66–68
DOI: https://doi.org/10.71267/mencom.7522 (Mi mendc1345)

Communications

Synthesis and biological activity of thiazole–carbohydrate conjugates based on thiacarpine, an analogue of the cytotoxic alkaloid from the ascidian Polycarpa aurata

D. N. Pelageev^a, S. M. Kovach^ab, N. N. Balaneva^a, Yu. E. Sabutski^a, K. L. Borisova^a, E. S. Menchinskaya^a, E. A. Chingizova^a, A. R. Chingizov^a, A. L. Burylova^c, O. Yu. Slabko^b, K. A. Drozdov^a, V. Ph. Anufriev^a

^a G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Russian Academy of Sciences, 690022 Vladivostok, Russian Federation
^b Institute of High Technologies and Advanced Materials, Far Eastern Federal University, 690922 Vladivostok, Russian Federation
^c Institute of the World Ocean, Far Eastern Federal University, 690922 Vladivostok, Russian Federation

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DOI: https://doi.org/10.71267/mencom.7522

Graphic abstract: Synthesis and biological activity of thiazole–carbohydrate conjugates based on thiacarpine, an analogue of the cytotoxic alkaloid from the ascidian <em>Polycarpa aurata</em>

Abstract: Based on bis(2-amino-4-phenyl-5-thiazolyl) disulfides, thiazole analogues of polycarpine, a cytotoxic alkaloid from the ascidian Polycarpa aurata, a wide range of thiazole–carbohydrate conjugates based on D-glucose and D-xylose has been obtained. Antitumor and antimicrobial activity for the synthesized compounds has been studied.

Keywords: polycarpine, thiacarpine, bis(2-amino-4-phenyl-5-thiazolyl)disulfide, thioglycosides, Polycarpa aurata.

Funding agency	Grant number
Russian Science Foundation	23-23-00357

Received: 05.06.2024
Accepted: 30.07.2024

Published: 24.01.2025

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Document Type: Article

Language: English

*Supplementary materials:*
		Supplementary_data_1.pdf	(2.9 Mb)

Citation: D. N. Pelageev, S. M. Kovach, N. N. Balaneva, Yu. E. Sabutski, K. L. Borisova, E. S. Menchinskaya, E. A. Chingizova, A. R. Chingizov, A. L. Burylova, O. Yu. Slabko, K. A. Drozdov, V. Ph. Anufriev, “Synthesis and biological activity of thiazole–carbohydrate conjugates based on thiacarpine, an analogue of the cytotoxic alkaloid from the ascidian Polycarpa aurata”, Mendeleev Commun., 35:1 (2025), 66–68

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