G. B. Lapa, A. A. Lapa, “Synthesis and biological evaluation of new N-substituted 4-(arylmethoxy)piperidines as dopamine transporter inhibitors”, Mendeleev Commun., 29:2 (2019), 203

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Mendeleev Communications, 2019, Volume 29, Issue 2, Pages 203–205
DOI: https://doi.org/10.1016/j.mencom.2019.03.030 (Mi mendc1472)

This article is cited in 1 scientific paper (total in 1 paper)

Communications

Synthesis and biological evaluation of new N-substituted 4-(arylmethoxy)piperidines as dopamine transporter inhibitors

G. B. Lapa^a, A. A. Lapa^b

^a N.I. Pirogov Russian National Research Medical University, Moscow, Russian Federation
^b Sandoz Pharmaceutical, Moscow, Russian Federation

Full-text PDF (491 kB) Citations (1) Supplementary materials

DOI: https://doi.org/10.1016/j.mencom.2019.03.030

Graphic abstract: Synthesis and biological evaluation of new N-substituted 4-(arylmethoxy)piperidines as dopamine transporter inhibitors

Abstract: The library of new N-substituted 4-(arylmethoxy)piperidines as dopamine transporter inhibitors was designed and synthesized. H-Bond donors in piperidine ring were found to be important for reduced locomotor activity in mice. 4-[Bis(4-fluorophenyl)methoxy]piperidine has IC₅₀ 17.0±1.0nm for dopamine transporter and locomotor activity, which is lower than that for cocaine.

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Document Type: Article

Language: English

*Supplementary materials:*
		Supplementary_data_1.pdf	(358.0 Kb)

Citation: G. B. Lapa, A. A. Lapa, “Synthesis and biological evaluation of new N-substituted 4-(arylmethoxy)piperidines as dopamine transporter inhibitors”, Mendeleev Commun., 29:2 (2019), 203–205

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https://www.mathnet.ru/eng/mendc1472

https://www.mathnet.ru/eng/mendc/v29/i2/p203

This publication is cited in the following 1 articles:

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