Synthesis of glycans functioning as antigens of the ABO blood group system

Since the discovery of carbohydrate nature of the antigens related to ABO blood group system in the middle of 20^th century, an interest to synthetic approaches to these oligosaccharides is very high. ABH glycans are required for clinical applications, namely, immunoadsorption and blood typing, as well as for scientific investigations in the areas of hematology, immunology and glycobiology. In this article, the chemical syntheses of various ABH glycans and related structures are reviewed, and examples of their use for clinical purposes are collected.