Abstract:
A series of 1-[(bromophenoxy)alkyl]uracil–coumarin conjugates has been obtained through the preparation of starting 1-[(bromophenoxy)alkyl]uracil derivatives, followed by their treatment with 7-(ω-bromoalkoxy)-4-methyl-2H-chromen-2-ones. Two of the synthesized uracil–coumarin conjugates demonstrated a pronounced inhibitory activity against HCMV and VZV replication in vitro.
Citation:
M. P. Paramonova, A. A. Ozerov, A. O. Chizhov, R. Snoeck, G. Andrei, A. L. Khandazhinskaya, M. S. Novikov, “Synthesis of uracil–coumarin conjugates as potential inhibitors of virus replication”, Mendeleev Commun., 29:6 (2019), 638–639
Linking options:
https://www.mathnet.ru/eng/mendc1613
https://www.mathnet.ru/eng/mendc/v29/i6/p638
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