Abstract:
An acid-catalyzed three-component reaction between hypophosphorous acid, aldehydes and alkyl carbamates under mild conditions afforded bis(α-aminoalkyl)phosphinic acids. The proposed facile single-stage protocol is prospective for expansion of a range of phosphinic analogues of HIV protease inhibitors.
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Document Type:
Article
Language: English
Citation:
A. V. Vinyukov, A. V. Borodachev, A. S. Starikov, A. V. Afanasyev, M. E. Dmitriev, B. V. Lednev, V. V. Ragulin, “An efficient one-pot synthesis of bis(α-aminoalkyl)phosphinic acids, phosphorus-isosteric analogues of HIV protease inhibitors”, Mendeleev Commun., 28:3 (2018), 295–296
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https://www.mathnet.ru/eng/mendc1743
https://www.mathnet.ru/eng/mendc/v28/i3/p295
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