Abstract:
Diastereoselective synthesis of racemic and enantiopure 3-aryl-5-ethyl-1,4,2-oxazaphosphorines, including those bearing phenolic hydroxyl groups in the exocyclic aromatic fragment, was implemented by the reaction of imines derived from (±)-and (R)-(−)-2-aminobutan-1-ol and (hydroxy)benzaldehydes with triethyl phosphite and trifluoroacetic acid, followed by the one-pot dealkylation of the intermediate esters.
Citation:
K. E. Metlushka, D. N. Sadkova, K. A. Nikitina, Z. R. Yamaleeva, K. A. Ivshin, O. N. Kataeva, V. A. Alfonsov, “A new synthetic route to chiral 3-aryl-5-ethyl-1,4,2-oxazaphosphorines”, Mendeleev Commun., 28:6 (2018), 579–581
Linking options:
https://www.mathnet.ru/eng/mendc1841
https://www.mathnet.ru/eng/mendc/v28/i6/p579
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