Structure–activity relationships of key bioantioxidants in reactions with radicals in DPPH, AAPH, and Hb–H2O2 systems

A comparative study of three systems based on various free radicals (AAPH azo initiator, hemoglobin–hydrogen peroxide, and DPPH) was performed by examining the kinetic and analytical properties of several significant bioantioxidants treated with these radicals. Common trends in structure–activity relationships for all three methods were shown. The measured data suggest a possibility of extrapolating the results obtained from one of the three methods to another when analyzing different chemical and biological objects.