Abstract:
The total synthesis of lembehyne B was accomplished in five steps in 51% total yield. The cross-cyclomagnesiation of two allenic components, nonadeca-1,2-diene and pentadeca-13,14-dien-1-ol tetrahydropyranyl ether, with EtMgBr in the presence of Mg and Cp2TiCl2 catalyst (10 mol%) was used in the key step of the synthesis.
Citation:
V. A. D'yakonov, A. A. Makarov, L. U. Dzhemileva, E. N. Andreev, U. M. Dzhemilev, “The first total synthesis of lembehyne B”, Mendeleev Commun., 27:2 (2017), 122–124
Linking options:
https://www.mathnet.ru/eng/mendc1916
https://www.mathnet.ru/eng/mendc/v27/i2/p122
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