D. O. Prima, E. V. Vorontsova, A. G. Makarov, A. Yu. Makarov, I. Yu. Bagryanskaya, T. F. Mikhailovskaya, Yu. G. Slizhov, A. V. Zibarev, “Halogenated (F, Cl) 1,3-benzodiazoles, 1,2,3-benzotriazoles, 2,1,3-benzothia(selena)diazoles and 1,4-benzodiazines inducing Hep2 cell apoptosis”, Mendeleev Commun., 27:5 (2017), 439

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Mendeleev Communications, 2017, Volume 27, Issue 5, Pages 439–442
DOI: https://doi.org/10.1016/j.mencom.2017.09.002 (Mi mendc2019)

This article is cited in 22 scientific papers (total in 22 papers)

Communications

Halogenated (F, Cl) 1,3-benzodiazoles, 1,2,3-benzotriazoles, 2,1,3-benzothia(selena)diazoles and 1,4-benzodiazines inducing Hep2 cell apoptosis

D. O. Prima^ab, E. V. Vorontsova^c, A. G. Makarov^a, A. Yu. Makarov^a, I. Yu. Bagryanskaya^ad, T. F. Mikhailovskaya^a, Yu. G. Slizhov^b, A. V. Zibarev^ab

^a N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation
^b Department of Chemistry, National Research Tomsk State University, Tomsk, Russian Federation
^c Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russian Federation
^d Department of Natural Sciences, Novosibirsk State University, Novosibirsk, Russian Federation

Full-text PDF (552 kB) Citations (22) Supplementary materials

DOI: https://doi.org/10.1016/j.mencom.2017.09.002

Graphic abstract: Halogenated (F, Cl) 1,3-benzodiazoles, 1,2,3-benzotriazoles, 2,1,3-benzothia(selena)diazoles and 1,4-benzodiazines inducing Hep2 cell apoptosis

Abstract: The title compounds synthesized from halogenated arene-1,2-diamines revealed, together with the latter, cytotoxicity towards the Hep2 (laryngeal epidermoid carcinoma) cells. The cytotoxicity was high and was accompanied by pronounced apoptotic activity at low concentrations for fluorinated diazoles, triazoles and selenadiazoles.

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Document Type: Article

Language: English

*Supplementary materials:*
		Supplementary_data_1.pdf	(795.4 Kb)

Citation: D. O. Prima, E. V. Vorontsova, A. G. Makarov, A. Yu. Makarov, I. Yu. Bagryanskaya, T. F. Mikhailovskaya, Yu. G. Slizhov, A. V. Zibarev, “Halogenated (F, Cl) 1,3-benzodiazoles, 1,2,3-benzotriazoles, 2,1,3-benzothia(selena)diazoles and 1,4-benzodiazines inducing Hep2 cell apoptosis”, Mendeleev Commun., 27:5 (2017), 439–442

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This publication is cited in the following 22 articles:

Citing articles in Google Scholar: Russian citations, English citations
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