Abstract:
The readily available Corey lactone was converted in three simple stages to tris-TBS-ether of (1R*,3R*,5S*)-1-hydroxymethyl-3,5-dihydroxy-2-methylidenecyclopentane – the protected carbocyclic core of Entecavir, one of the best medicines against hepatitis.
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Document Type:
Article
Language: English
Citation:
Z. R. Valiullina, V. A. Akhmet'yanova, N. S. Vostrikov, M. S. Miftakhov, “A short synthesis of the carbocyclic core of Entecavir from Corey lactone”, Mendeleev Commun., 26:1 (2016), 9–10
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https://www.mathnet.ru/eng/mendc2091
https://www.mathnet.ru/eng/mendc/v26/i1/p9
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