Abstract:
Recent data about structure, interaction with biometals, aggregation state, proteolysis by angiotensin converting enzyme, neurotoxicity and amyloidogenicity of amyloid-β containing isoaspartate 7 (isoAsp7-Aβ) in comparison with intact amyloid-β are summarized. Possible role of isoAsp7-Aβ as a prospective biomarker for molecular diagnostics and drug target in anti-amyloid therapy of Alzheimer's disease is discussed.
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Document Type:
Article
Language: English
Citation:
S. A. Kozin, V. A. Mitkevich, A. A. Makarov, “Amyloid-β containing isoaspartate 7 as potential biomarker and drug target in Alzheimer's disease”, Mendeleev Commun., 26:4 (2016), 269–275
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https://www.mathnet.ru/eng/mendc2183
https://www.mathnet.ru/eng/mendc/v26/i4/p269
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