New insight into the antiaggregant activity of furoxans

The measurement of the antiaggregant properties of 3-cyano-4-phenylfuroxan and 3-nitro-4-phenylfuroxan has demonstrated that these compounds effectively inhibit platelet agglutination induced by adenosine diphosphate and adrenaline but not ristocetin. When collagen was used as an inducer, only a slight delay of aggregate formation was observed. Therefore, these furoxan derivatives could be considered as a basis for the development of next generation agents with improved antiaggregant activity.