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This article is cited in 6 scientific papers (total in 6 papers)
Synthesis and biological testing of conformationally restricted serotonin analogues with bridgehead moieties
O. N. Zefirovaab, T. Yu. Baranovaa, K. A. Lyssenkoc, N. A. Zefirova, N. V. Zyka, P. M. Vassilievd, D. S. Yakovlevd, A. A. Spasovd
a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
b Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation
c A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Moscow, Russian Federation
d Volgograd State Medical University, Volgograd, Russian Federation
Abstract:
The synthesis of conformationally restricted serotonin analogues based on indol derivatives annelated with bicyclo[3.3.1]nonane and bicyclo[3.2.1]octane moieties is described. The configuration of the amino group in a structure is proved on the basis of X-ray data for N- [(9R)-2-methoxy-6,7,8,9,10,11-hexahydro-5H-6,10-methanocycloocta[b]indol-9-yl]acetamide. The ex vivo testing results of four products to 5HT3 serotonin receptors are presented.
Citation:
O. N. Zefirova, T. Yu. Baranova, K. A. Lyssenko, N. A. Zefirov, N. V. Zyk, P. M. Vassiliev, D. S. Yakovlev, A. A. Spasov, “Synthesis and biological testing of conformationally restricted serotonin analogues with bridgehead moieties”, Mendeleev Commun., 22:2 (2012), 75–77
Linking options:
https://www.mathnet.ru/eng/mendc2744 https://www.mathnet.ru/eng/mendc/v22/i2/p75
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