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This article is cited in 1 scientific paper (total in 1 paper)
Modification of g-Aminobutyric Acid with Acylacetylenes: Stereoselective C-Vinylation of the Primary Adducts and Transformation to Acylpyridines
T. E. Glotova, M. Yu. Dvorko, I. A. Ushakov, D. A. Shabalin, E. Yu. Schmidt, B. A. Trofimov
A.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, Irkutsk, Russian Federation
Abstract:
Primary N–C adducts of g-aminobutyric acid (GABA) to acylacetylenes undergo mild stereoselective C-vinylation by another acylacetylene molecule to afford (2E,4Z)-4-acyl-5-aminoalka-2,4-dien-1-one-type diadducts in 83–92% yields. The latter cyclize to acylpyridines in up to 89% yields with the C–N bond cleavage in the GABA moiety and elimination of g-butyrolactone.
Citation:
T. E. Glotova, M. Yu. Dvorko, I. A. Ushakov, D. A. Shabalin, E. Yu. Schmidt, B. A. Trofimov, “Modification of g-Aminobutyric Acid with Acylacetylenes: Stereoselective C-Vinylation of the Primary Adducts and Transformation to Acylpyridines”, Mendeleev Commun., 22:6 (2012), 314–316
Linking options:
https://www.mathnet.ru/eng/mendc2833 https://www.mathnet.ru/eng/mendc/v22/i6/p314
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