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This article is cited in 13 scientific papers (total in 13 papers)
New functionalized aminofurazans as potential antimitotic agents in the sea urchin embryo assay
A. B. Sheremeteva, D. E. Dmitrieva, N. K. Lagutinaa, M. M. Raikhshtata, A. S. Kiselevb, M. N. Semenovac, N. N. Ikizalpd, V. V. Semenovad a N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
b deCODE Chemistry, Chicago, IL60517, USA
c N.K. Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russian Federation
d Chemical Block Ltd., Limassol, Cyprus
Abstract:
A series of new furazan (1,2,5-oxadiazole) derivatives based on structural overlap with combretastatin have been synthesized. Targeted molecules were evaluated using the sea urchin embryo assay; several agents demonstrated 1–4μmol dm–3 antiproliferative activity in this in vivo model.
Citation:
A. B. Sheremetev, D. E. Dmitriev, N. K. Lagutina, M. M. Raikhshtat, A. S. Kiselev, M. N. Semenova, N. N. Ikizalp, V. V. Semenov, “New functionalized aminofurazans as potential antimitotic agents in the sea urchin embryo assay”, Mendeleev Commun., 20:3 (2010), 132–134
Linking options:
https://www.mathnet.ru/eng/mendc3013 https://www.mathnet.ru/eng/mendc/v20/i3/p132
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