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This article is cited in 18 scientific papers (total in 18 papers)
Design, synthesis and biotest of a bicyclo[3.3.1]nonane analogue of 2-amino-5,6-dihydro-4H-1,3-thiazine
O. N. Zefirovaab, E. V. Nurievaa, V. I. Chupakhinb, I. S. Semenovaa, D. I. Peregudc, M. V. Onufrievd, N. V. Gulyaevad a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
b Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation
c National Research Center on Addictions, Ministry of Health and Social Development of the Russian Federation, Moscow, Russian Federation
d Institute for Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russian Federation
Abstract:
To enhance the lipophilicity of the NO-synthase inhibitor 2-amino-5,6-dihydro-4H-1,3-thiazine, its bridgehead analogue was suggested on the basis of molecular modeling; the synthetic routes to new 3-thia-1-azabicyclo[3.3.1]nonane derivatives and the results of their biological testing are presented.
Citation:
O. N. Zefirova, E. V. Nurieva, V. I. Chupakhin, I. S. Semenova, D. I. Peregud, M. V. Onufriev, N. V. Gulyaeva, “Design, synthesis and biotest of a bicyclo[3.3.1]nonane analogue of 2-amino-5,6-dihydro-4H-1,3-thiazine”, Mendeleev Commun., 20:6 (2010), 323–325
Linking options:
https://www.mathnet.ru/eng/mendc3080 https://www.mathnet.ru/eng/mendc/v20/i6/p323
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