D. B. Shpakovsky, D. A. Berseneva, Yu. A. Gracheva, T. A. Antonenko, Yu. F. Oprunenko, V. V. Britikov, E. V. Britikova, E. R. Milaeva, “Synthesis and antiproliferative activity of novel organotin complexes bearing abiraterone drug moiety”, Mendeleev Commun., 34:1 (2024), 22

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Mendeleev Communications, 2024, Volume 34, Issue 1, Pages 22–24
DOI: https://doi.org/10.1016/j.mencom.2024.01.007 (Mi mendc32)

This article is cited in 4 scientific papers (total in 4 papers)

Communications

Synthesis and antiproliferative activity of novel organotin complexes bearing abiraterone drug moiety

D. B. Shpakovsky^a, D. A. Berseneva^a, Yu. A. Gracheva^a, T. A. Antonenko^a, Yu. F. Oprunenko^a, V. V. Britikov^b, E. V. Britikova^b, E. R. Milaeva^a

^a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Minsk, Belarus

Full-text PDF (636 kB) Citations (4) Supplementary materials

DOI: https://doi.org/10.1016/j.mencom.2024.01.007

Graphic abstract: Synthesis and antiproliferative activity of novel organotin complexes bearing abiraterone drug moiety

Abstract: Novel organotin(iv) complexes based on anticancer drug abiraterone acetate and abiraterone incorporating semipolar N→Sn bond at the pyridine moiety were synthesized and characterized. In vitro antiproliferative activity of the complexes against human cancer and normal cell lines was evaluated, the complexes with triphenyltin moiety being the most active (IC₅₀ is in the range of 120–430 nm). Compounds actively induced apoptosis and blocked proliferation in the G2/M phase of the cell cycle.

Keywords: organotin complexes, abiraterone, prostate cancer, antiproliferative activity, apoptosis, cell cycle.

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Document Type: Article

Language: English

*Supplementary materials:*
		Supplementary_data_1.pdf	(2.2 Mb)

Citation: D. B. Shpakovsky, D. A. Berseneva, Yu. A. Gracheva, T. A. Antonenko, Yu. F. Oprunenko, V. V. Britikov, E. V. Britikova, E. R. Milaeva, “Synthesis and antiproliferative activity of novel organotin complexes bearing abiraterone drug moiety”, Mendeleev Commun., 34:1 (2024), 22–24

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https://www.mathnet.ru/eng/mendc/v34/i1/p22

This publication is cited in the following 4 articles:

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