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Mendeleev Communications, 2023, Volume 33, Issue 1, Pages 109–111
DOI: https://doi.org/10.1016/j.mencom.2023.01.034 (Mi mendc323) 		 
This article is cited in 2 scientific papers (total in 2 papers)

Communications

Urea derivatives of spirocyclic piperidines endowed with antibacterial activity

A. Lukina, K. Komarovaa, L. Vinogradovaa, E. Rogachevab, L. Kraevab, M. Dogonadgec, T. Vinogradovac, M. Krasavinde

a M.V. Lomonosov Institute of Fine Chemical Technologies, MIREA - Russian Technological University, Moscow, Russian Federation
b St. Petersburg Pasteur Institute, St. Petersburg, Russian Federation
c St. Petersburg Research Institute of Phthisiopulmonology, St. Petersburg, Russian Federation
d Immanuel Kant Baltic Federal University, Kaliningrad, Russian Federation
e Institute of Chemistry, St. Petersburg State University, St. Petersburg, Russian Federation
Full-text PDF (221 kB) Citations (2) Supplementary materials
DOI: https://doi.org/10.1016/j.mencom.2023.01.034
Abstract: Antimycobacterial activity of certain ureas as well as spirocyclic piperidines described in the literature prompted us to synthesize and test a series of hybrids of spirocyclic piperidine with ureas. Surprisingly, no activity was detected against Mycobacterium tuberculosis. However, significant antibacterial activity was identified and confirmed against common gram-positive as well as gram-negative bacteria.
Keywords: spirocyclic compounds, piperidines, ureas, epoxide hydrolase, membrane transporter Mmpl3, antimycobacterial activity, antibacterial activity.
Bibliographic databases:
Document Type: Article
Language: English
Supplementary materials:
Supplementary_data_1.pdf (3.4 Mb)


Citation: A. Lukin, K. Komarova, L. Vinogradova, E. Rogacheva, L. Kraeva, M. Dogonadge, T. Vinogradova, M. Krasavin, “Urea derivatives of spirocyclic piperidines endowed with antibacterial activity”, Mendeleev Commun., 33:1 (2023), 109–111
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    • This publication is cited in the following 2 articles:
    Citing articles in Google Scholar: Russian citations, English citations
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