A. E. M. Mekky, Sh. M. H. Sanad, “Antibacterial screening of new bis(pyrazolo[1,5-a]pyrimidine) hybrids linked to different spacers”, Mendeleev Commun., 33:3 (2023), 331

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Mendeleev Communications, 2023, Volume 33, Issue 3, Pages 331–333
DOI: https://doi.org/10.1016/j.mencom.2023.04.011 (Mi mendc388)

This article is cited in 9 scientific papers (total in 9 papers)

Communications

Antibacterial screening of new bis(pyrazolo[1,5-a]pyrimidine) hybrids linked to different spacers

A. E. M. Mekky, Sh. M. H. Sanad

Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt

Full-text PDF (202 kB) Citations (9) Supplementary materials

DOI: https://doi.org/10.1016/j.mencom.2023.04.011

Graphic abstract: Antibacterial screening of new bis(pyrazolo[1,5-<i>a</i>]pyrimidine) hybrids linked to different spacers

Abstract: A three-component protocol was adopted to efficiently prepare new bis(pyrazolo[1,5-a]pyrimidines) linked to different spacers in 80-92% yields from 1H-pyrazole-3,5-diamines, malononitrile and bis(aldehydes). The p-xylene-linked bis(pyrimidine) bearing 3-positioned 4-methoxy-benzyl substituent had the best antibacterial activity with MIC / MBC values up to 2.2 / 4.4 µm.

Keywords: bis(aldehyde), pyrazolo[1,5-a]pyrimidine, multicomponent reactions, aza-Michael addition, α-unsaturated nitriles, heterocyclization, 1 3-dielectrophiles, in vitro antibacterial screening.

Bibliographic databases:

Document Type: Article

Language: English

*Supplementary materials:*
		Supplementary_data_1.pdf	(1.8 Mb)

Citation: A. E. M. Mekky, Sh. M. H. Sanad, “Antibacterial screening of new bis(pyrazolo[1,5-a]pyrimidine) hybrids linked to different spacers”, Mendeleev Commun., 33:3 (2023), 331–333

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https://www.mathnet.ru/eng/mendc388

https://www.mathnet.ru/eng/mendc/v33/i3/p331

This publication is cited in the following 9 articles:

Citing articles in Google Scholar: Russian citations, English citations
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