Mendeleev Communications
RUS  ENG    JOURNALS   PEOPLE   ORGANISATIONS   CONFERENCES   SEMINARS   VIDEO LIBRARY   PACKAGE AMSBIB  
General information
Latest issue
Archive

Search papers
Search references

RSS
Latest issue
Current issues
Archive issues
What is RSS


Mendeleev Commun.:
Year:
Volume:
Issue:
Page:
Find




Personal entry:
Login:
Password:
Save password
Enter
Forgotten password?
Register

Mendeleev Communications, 2023, Volume 33, Issue 3, Pages 334–336
DOI: https://doi.org/10.1016/j.mencom.2023.04.012 (Mi mendc389) 		 
This article is cited in 2 scientific papers (total in 2 papers)

Communications

Substituted cinnamides: Characterization of non-toxic inhibitors of alpha-synuclein aggregation

A. Konstantinovaa, V. Stroylovbc, D. Pozdyshevd, M. Sovae, S. A. Akbarf, V. Muronetzd, Yu. Stroylovadg

a Department of Biotechnology, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
b N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
c National Research University Higher School of Economics (HSE University), Moscow, Russian Federation
d A.N. Belozersky Research Institute of Physico-Chemical Biology, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
e Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia
f Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
g Institute of Molecular Medicine, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation
Full-text PDF (733 kB) Citations (2)
DOI: https://doi.org/10.1016/j.mencom.2023.04.012
Abstract: Four substituted cinnamides were studied as potential inhibitors of alpha-synuclein aggregation. (E)-3-[3-(Benzo[d][1,3]dioxol-5-yl)acrylamido]benzoic acid (SMB11) was shown to inhibit amyloid fibril formation of recombinant human alpha-synuclein according to Congo Red and partial proteolysis by proteinase K assays. This compound and its analog with 3-trifluoromethylphenyl substituent demonstrated no cytotoxicity on human neuroblastoma SH-SY5Y cells.
Keywords: alpha-synuclein, amyloid aggregation, cinnamides, surface docking, Parkinson’s disease.
Bibliographic databases:
Document Type: Article
Language: English


Citation: A. Konstantinova, V. Stroylov, D. Pozdyshev, M. Sova, S. A. Akbar, V. Muronetz, Yu. Stroylova, “Substituted cinnamides: Characterization of non-toxic inhibitors of alpha-synuclein aggregation”, Mendeleev Commun., 33:3 (2023), 334–336
Linking options:
  • https://www.mathnet.ru/eng/mendc389
  • https://www.mathnet.ru/eng/mendc/v33/i3/p334
    • This publication is cited in the following 2 articles:
    Citing articles in Google Scholar: Russian citations, English citations
    Related articles in Google Scholar: Russian articles, English articles
    		Mendeleev Communications
     
      Contact us:
    		  Terms of Use  Registration to the website  Logotypes © Steklov Mathematical Institute RAS, 2025