The conversion of achiral molecules in chiral crystals to chiral molecules

N,N-Diisopropylbenzoylformamide, benzil, and 4,4′-dimethylchalcone are achiral molecules that crystallize in chiral space groups. It is possible with suitable reagents in water to convert these molecules in the crystals directly into chiral molecules. In the case of the chalcone asymmetric induction in its reaction is observed.