R. J.-R. Hwu, Sh.-Ch. Tsay, T. Sambaiah, Y.-K. Lai, Ch.-H. Lieu, G. H. Hakimelahi, K.-Yu. King, “Design and synthesis of paclitaxel-containing aminoester phosphate and phosphoamidate”, Mendeleev Commun., 11:6 (2001), 216

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Mendeleev Communications, 2001, Volume 11, Issue 6, Pages 216–217
DOI: https://doi.org/10.1070/MC2001v011n06ABEH001498 (Mi mendc4302)

This article is cited in 1 scientific paper (total in 1 paper)

Design and synthesis of paclitaxel-containing aminoester phosphate and phosphoamidate

R. J.-R. Hwu^a, Sh.-Ch. Tsay^b, T. Sambaiah^a, Y.-K. Lai^c, Ch.-H. Lieu^c, G. H. Hakimelahi^b, K.-Yu. King^b

^a Organosilicon and Synthesis Laboratory, Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan, Republic of China
^b Institute of Chemistry, Academia Sinica, Nankang, Taipai, Taiwan, Republic of China
^c Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan, Republic of China

Full-text PDF (100 kB) Citations (1)

DOI: https://doi.org/10.1070/MC2001v011n06ABEH001498

Abstract: Paclitaxel-containing aminoester phosphate 4 and phosphoamidate 9 were synthesised and found to possess anticancer activity against HL-60 leukemia cells; their solubility in a phosphate buffer solution was about 16 times higher than that of paclitaxel.

Document Type: Article

Language: English

Citation: R. J.-R. Hwu, Sh.-Ch. Tsay, T. Sambaiah, Y.-K. Lai, Ch.-H. Lieu, G. H. Hakimelahi, K.-Yu. King, “Design and synthesis of paclitaxel-containing aminoester phosphate and phosphoamidate”, Mendeleev Commun., 11:6 (2001), 216–217

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