Synthesis of daidzein derivatives for targeted drug delivery

A new protocol was developed for the synthesis of daidzein derivatives bearing 7-positioned linkers with carboxy and amino functions. The key step of the scheme is the Suzuki cross-coupling, the optimized procedures provide high yields and do not require chromatographic purification. This approach is advantageous for further linker elongation necessary for anchoring and drug-coupling; the compounds obtained are regarded as tumor-directing carriers.