N. A. Zefirov, A. Glassl, E. V. Radchenko, A. N. Borovik, V. V. Stanishevskiy, E. R. Milaeva, S. A. Kuznetsov, O. N. Zefirova, “Podophyllotoxin esters with alicyclic residues: an insight into the origin of microtubule-curling effect in cancer cells”, Mendeleev Commun., 32:2 (2022), 173

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Mendeleev Communications, 2022, Volume 32, Issue 2, Pages 173–175
DOI: https://doi.org/10.1016/j.mencom.2022.03.006 (Mi mendc603)

This article is cited in 10 scientific papers (total in 10 papers)

Communications

Podophyllotoxin esters with alicyclic residues: an insight into the origin of microtubule-curling effect in cancer cells

N. A. Zefirov^a, A. Glassl^b, E. V. Radchenko^a, A. N. Borovik^a, V. V. Stanishevskiy^a, E. R. Milaeva^a, S. A. Kuznetsov^b, O. N. Zefirova^a

^a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b Institute of Biological Sciences, Cell Biology and Biosystems Technology, University of Rostock, Rostock, Germany

Full-text PDF (787 kB) Citations (10) Supplementary materials

DOI: https://doi.org/10.1016/j.mencom.2022.03.006

Graphic abstract: Podophyllotoxin esters with alicyclic residues: an insight into the origin of microtubule-curling effect in cancer cells

Abstract: Immunofluorescent microscopy of cancer cells A549 treated with novel alicyclic (mostly bridged) podophyllotoxin C⁴-esters at different concentrations gave evidence that the ‘curling’ of microtubules occurred at one of the first steps of their depolymerisation. Molecular dynamics study revealed the differences in curved conformations of tubulin dimer in a complex with adamantane-comprising ester and in a complex with podophyllotoxin.

Keywords: Molecular dynamics, Podophyllotoxin, Alicyclic compounds, Esters, Bridged moieties, Tubulin, Microtubules, Human lung carcinoma A549, Immunofluorescence microscopy.

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Document Type: Article

Language: English

*Supplementary materials:*
		Supplementary_data_1.pdf	(1.0 Mb)

Citation: N. A. Zefirov, A. Glassl, E. V. Radchenko, A. N. Borovik, V. V. Stanishevskiy, E. R. Milaeva, S. A. Kuznetsov, O. N. Zefirova, “Podophyllotoxin esters with alicyclic residues: an insight into the origin of microtubule-curling effect in cancer cells”, Mendeleev Commun., 32:2 (2022), 173–175

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https://www.mathnet.ru/eng/mendc/v32/i2/p173

This publication is cited in the following 10 articles:

Citing articles in Google Scholar: Russian citations, English citations
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