N. Yu. Zyk, A. Yu. Kolchanova, N. S. Volkova, A. A. Uspenskaia, D. A. Skvortsov, E. K. Beloglazkina, N. V. Zyk, A. G. Majouga, A. E. Machulkin, “A novel molecular platform for co-delivery of monomethyl auristatin E and ispinesib to prostate cancer cells”, Mendeleev Commun., 35:4 (2025), 440

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Mendeleev Communications, 2025, Volume 35, Issue 4, Pages 440–443
DOI: https://doi.org/10.71267/mencom.7661 (Mi mendc6111)

Communications

A novel molecular platform for co-delivery of monomethyl auristatin E and ispinesib to prostate cancer cells

N. Yu. Zyk^a, A. Yu. Kolchanova^a, N. S. Volkova^a, A. A. Uspenskaia^a, D. A. Skvortsov^a, E. K. Beloglazkina^a, N. V. Zyk^a, A. G. Majouga^b, A. E. Machulkin^ac

^a Department of Chemistry, M. V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation
^b D. I. Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russian Federation
^c Peoples Friendship University of Russia (RUDN University), 117198 Moscow, Russian Federation

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DOI: https://doi.org/10.71267/mencom.7661

Graphic abstract: A novel molecular platform for co-delivery of monomethyl auristatin E and ispinesib to prostate cancer cells

Abstract: A conjugate for co-delivery of ispinesib and monomethyl auristatin E was prepared using methods of peptide synthesis and azide–alkyne cycloaddition. Cytotoxicity studies of the mentioned drug pair were performed. In vitro studies of the synthesized bimodal conjugate were conducted on prostate cancer cell lines.

Keywords: prostate cancer, prostate specific membrane antigen, bimodal conjugates, monomethyl auristatin E, ispinesib, peptide synthesis, azide–alkyne cycloaddition.

Funding agency	Grant number
Russian Science Foundation	24-23-00156

Received: 21.10.2024
Accepted: 05.12.2024

Published: 21.05.2025

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Document Type: Article

Language: English

*Supplementary materials:*
		Supplementary_data_1.pdf	(2.1 Mb)

Citation: N. Yu. Zyk, A. Yu. Kolchanova, N. S. Volkova, A. A. Uspenskaia, D. A. Skvortsov, E. K. Beloglazkina, N. V. Zyk, A. G. Majouga, A. E. Machulkin, “A novel molecular platform for co-delivery of monomethyl auristatin E and ispinesib to prostate cancer cells”, Mendeleev Commun., 35:4 (2025), 440–443

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