Abstract:
An efficient and selective access to novel $\alpha$-CF$_3$-substituted $\gamma$,$\delta$-didehydro lysine derivatives and their phosphorus analogues has been developed via the Cu-catalyzed Mannich reaction of $\alpha$-amino $\alpha$-propargyl $\alpha$-trifluoromethyl carboxylates or phosphonates with different secondary amines and paraformaldehyde.
Citation:
A. N. Philippova, D. V. Vorobyeva, T. P. Vasilyeva, A. K. Mailyan, P. S. Gribanov, S. N. Osipov, “Synthesis of $\alpha$-CF$_3$-substituted $\gamma$,$\delta$-didehydro lysine derivatives”, Mendeleev Commun., 32:2 (2022), 260–261