N. M. Chobanov, L. U. Dzhemileva, K. O. Vakhnin, U. M. Dzhemilev, V. A. D’yakonov, “Synthesis and antitumor activity of bis-camptothecin ester of succinic acid”, Mendeleev Commun., 35:3 (2025), 289

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Mendeleev Communications, 2025, Volume 35, Issue 3, Pages 289–291
DOI: https://doi.org/10.71267/mencom.7641 (Mi mendc6691)

Communications

Synthesis and antitumor activity of bis-camptothecin ester of succinic acid

N. M. Chobanov^a, L. U. Dzhemileva^a, K. O. Vakhnin^b, U. M. Dzhemilev^a, V. A. D’yakonov^a

^a N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation
^b Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Moscow Region, Russian Federation

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DOI: https://doi.org/10.71267/mencom.7641

Graphic abstract: Synthesis and antitumor activity of bis-camptothecin ester of succinic acid

Abstract: New succinic diester containing two residues of antitumor alkaloid camptothecin has been synthesized. Its cytotoxicity and effect on cell cycle and induction of apoptosis were explored using modern methods of flow cytometry, as well as in vitro studies of the inhibitory activity against human topoisomerase I.

Keywords: camptothecin, succinic diester, hybrid molecules, cytotoxicity, cell cycle, apoptosis, topoisomerase I inhibitors, antitumor activity, flow cytometry.

Funding agency	Grant number
Russian Science Foundation	22-13-00160

Received: 09.10.2024
Accepted: 05.12.2024

Published: 31.03.2025

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Document Type: Article

Language: English

*Supplementary materials:*
		Supplementary_data_1.pdf	(1.4 Mb)

Citation: N. M. Chobanov, L. U. Dzhemileva, K. O. Vakhnin, U. M. Dzhemilev, V. A. D’yakonov, “Synthesis and antitumor activity of bis-camptothecin ester of succinic acid”, Mendeleev Commun., 35:3 (2025), 289–291

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