M. Yu. Krasavin, A. A. Shetnev, V. A. Panova, S. A. Ivanovskii, S. A. Kalinin, T. Vinogradova, V. V. Sharoyko, P. Yablonsky, “Hetaryl- and heteroarylvinyl-substituted nitrofurans identified as non-cytotoxic selective antitubercular agents”, Mendeleev Commun., 32:4 (2022), 452

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Mendeleev Communications, 2022, Volume 32, Issue 4, Pages 452–453
DOI: https://doi.org/10.1016/j.mencom.2022.07.008 (Mi mendc692)

This article is cited in 6 scientific papers (total in 6 papers)

Communications

Hetaryl- and heteroarylvinyl-substituted nitrofurans identified as non-cytotoxic selective antitubercular agents

M. Yu. Krasavin^a, A. A. Shetnev^b, V. A. Panova^b, S. A. Ivanovskii^b, S. A. Kalinin^a, T. Vinogradova^c, V. V. Sharoyko^a, P. Yablonsky^c

^a Institute of Chemistry, St. Petersburg State University, St. Petersburg, Russian Federation
^b K. D. Ushinsky Yaroslavl State Pedagogical University, Yaroslavl, Russian Federation
^c St. Petersburg Research Institute of Phthisiopulmonology, St. Petersburg, Russian Federation

Full-text PDF (165 kB) Citations (6) Supplementary materials

DOI: https://doi.org/10.1016/j.mencom.2022.07.008

Graphic abstract: Hetaryl- and heteroarylvinyl-substituted nitrofurans identified as non-cytotoxic selective antitubercular agents

Abstract: New (E)-5-[2-(5-nitrofuran-2-yl)vinyl]-1,2,4-oxadiazoles and 5-(5-nitrofuran-2-yl)-1,2,4-oxadiazoles were synthesized via the base-promoted condensation of nitrofuran-containing acyl chlorides with amidoximes. Testing these compounds against Gram-negative E. coli, Gram-positive B. subtilis and S. aureus as well as M. tuberculosis HRv37 strain revealed three compounds being selectively antimycobacterial. None of these compounds displayed any cytotoxicity towards human pancreatic epithelioid carcinoma cell line, PANC-1.

Keywords: nitrofurans, 124-oxadiazoles, amidoximes, olefin linker, direct bond, antibacterial assay, antimycobacterial assay, MTT assay, cell viability.

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Document Type: Article

Language: English

*Supplementary materials:*
		Supplementary_data_1.pdf	(1.9 Mb)

Citation: M. Yu. Krasavin, A. A. Shetnev, V. A. Panova, S. A. Ivanovskii, S. A. Kalinin, T. Vinogradova, V. V. Sharoyko, P. Yablonsky, “Hetaryl- and heteroarylvinyl-substituted nitrofurans identified as non-cytotoxic selective antitubercular agents”, Mendeleev Commun., 32:4 (2022), 452–453

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https://www.mathnet.ru/eng/mendc/v32/i4/p452

This publication is cited in the following 6 articles:

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